Emulsion (co) polymerization of styrene and butyl acrylate monitored by on-line Raman spectroscopy

2000 ◽  
Vol 150 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Mark van den Brink ◽  
Michel Pepers ◽  
Alex M. van Herk ◽  
Anton L. German
Keyword(s):  
Raman Spectroscopy ◽  
Butyl Acrylate ◽  
On Line

Measurement of partial conversions during the solution copolymerization of styrene and butyl acrylate using on-line raman spectroscopy

2000 ◽  
Vol 79 (3) ◽  
pp. 426-436 ◽  
Author(s):  
Mark Van ◽  
Den Brink ◽  
Jacques-Fran�ois Hansen ◽  
Peter De Peinder ◽  
Alex M. Van Herk ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Butyl Acrylate ◽  
On Line

Monitoring of High Solids Content Starved-Semi-Batch Emulsion Copolymerization Reactions by Fourier Transform Raman Spectroscopy

2005 ◽  
Vol 59 (10) ◽  
pp. 1270-1279 ◽  
Author(s):  
Oihana Elizalde ◽  
José M. Asua ◽  
Jose R. Leiza
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Butyl Acrylate ◽  
High Solids ◽  
Emulsion Copolymerization ◽  
Ft Raman Spectroscopy ◽  
On Line ◽  
Solids Content ◽  
High Solids Content ◽  
Ft Raman

A high solids content n-butyl acrylate/methyl methacrylate emulsion copolymerization process carried out under starved semi-batch conditions was for the first time monitored on-line by means of Fourier transform (FT)-Raman spectroscopy. Partial least squares regression was employed to build calibration models that allowed relating the spectra with solids content (overall conversion), free amounts of both n-butyl acrylate (n-BA) and methyl methacrylate (MMA), and cumulative copolymer composition. In spite of the heterogeneous nature of the polymerization, the similarities of the spectra for MMA, n-BA, and for the copolymer, and the low monomer concentrations in the reactor, the FT-Raman spectroscopy has been shown to be a suitable noninvasive sensor to accurately monitor the process. Therefore, it is well suited for on-line control of all-acrylic polymerization systems.

On-Line Monitoring of Airborne Chemistry in Levitated Nanodroplets:  In Situ Synthesis and Application of SERS-Active Ag−Sols for Trace Analysis by FT-Raman Spectroscopy

2003 ◽  
Vol 75 (9) ◽  
pp. 2166-2171 ◽  
Author(s):  
Nicolae Leopold ◽  
Michael Haberkorn ◽  
Thomas Laurell ◽  
Johan Nilsson ◽  
Josefa R. Baena ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Trace Analysis ◽  
In Situ Synthesis ◽  
Ft Raman Spectroscopy ◽  
On Line ◽  
Ft Raman

scholarly journals Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 683 ◽  
Author(s):  
Feidl ◽  
Garbellini ◽  
Luna ◽  
Vogg ◽  
Souquet ◽  
...  
Keyword(s):  
Experimental Data ◽  
Raman Spectroscopy ◽  
Estimation Procedure ◽  
Mechanistic Modeling ◽  
Spectroscopic Techniques ◽  
Chromatographic Purification ◽  
On Line ◽  
Filter Approach ◽  
Underlying Mechanisms ◽  
Combining Information

Chromatography is widely used in biotherapeutics manufacturing, and the corresponding underlying mechanisms are well understood. To enable process control and automation, spectroscopic techniques are very convenient as on-line sensors, but their application is often limited by their sensitivity. In this work, we investigate the implementation of Raman spectroscopy to monitor monoclonal antibody (mAb) breakthrough (BT) curves in chromatographic operations with a low titer harvest. A state estimation procedure is developed by combining information coming from a lumped kinetic model (LKM) and a Raman analyzer in the frame of an extended Kalman filter approach (EKF). A comparison with suitable experimental data shows that this approach allows for the obtainment of reliable estimates of antibody concentrations with reduced noise and increased robustness.

Microemulsion copolymerization of styrene-methyl methacrylate followed on line by low-resolution Raman spectroscopy

2009 ◽  
Vol 49 (11) ◽  
pp. 2125-2131 ◽  
Author(s):  
Miguel A. Corona-Rivera ◽  
Jorge Flores ◽  
Jorge E. Puig ◽  
Eduardo Mendizábal
Keyword(s):  
Raman Spectroscopy ◽  
Methyl Methacrylate ◽  
Low Resolution ◽  
On Line

scholarly journals Simultaneous Infrared Spectroscopy, Raman Spectroscopy and Luminescence Sensing: A Multi-Spectroscopic Analyti-cal Platform

2021 ◽  
Author(s):  
Sarah Klingler ◽  
Julian Hniopek ◽  
Robert Stach ◽  
Michael Schmitt ◽  
Jürgen Popp ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Environmental Chemistry ◽  
Attenuated Total Reflection ◽  
Liquid Volume ◽  
On Line ◽  
Atr Spectroscopy ◽  
Gas Tight ◽  
Scientific Questions ◽  
Minute Sample

Scientific questions in fields such as catalysis, monitoring of biological processes or environmental chemistry demand for analytical technologies combining orthogonal spectroscopies. Combined spectroscopic concepts facilitate in-situ on-line monitoring of dynamic processes providing for a better understanding of the involved reaction pathways. In the present study, a low-liquid-volume multi-spectroscopic platform was developed based on infrared attenuated total reflection (IR-ATR) spectroscopy combined with Raman spectroscopy and lumines-cence sensing. For demonstrating the measurement capabilities, exemplary analyte systems including water / heavy water and aqueous solutions of ammonium sulfate were analyzed as proof-of-principle studies. It was successfully demonstrated that three optical techniques may be integrated into a single analytical platform with-out interference providing synchronized and complementary datasets by probing the same minute sample vol-ume. In addition, the developed assembly provides a gas-tight lid sealing the headspace above the probed liq-uid for monitoring the concentration of molecular oxygen also in the gas phase via luminescence quenching. Hence, the entire assembly may be operated at inert conditions, as required for example during the analysis of photocatalytic processes.

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